Generic Name: Interferon Alfa-2a (in ter FEER on AL fa too aye). Contraindications. Tell your It may be given to you for other reasons. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. What are some other side effects of Interferon Alfa-2a? Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. These interferons have been classified into two types: type I includes the alpha and beta forms, and type II consists of the gamma form. Talk with the doctor. Last updated on Aug 21, 2020. ; It is often called interferon for short. In some cases, health care professionals may use the trade names Intron® A, Roferon®-A or other names such as IFN-alpha and alpha interferon when referring to the generic drug name interferon alfa. You may also report side effects at https://www.fda.gov/medwatch. to make sure that it is safe for you to take interferon alfa-2a with all of your drugs and health problems. Many times, but not every time, these side Hairy cell leukemia 5. Interferon alfa-2a dosage information (in more detail). The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. prednisone, methotrexate, dexamethasone, Keytruda, Imbruvica, hydroxyurea, cyclophosphamide, Revlimid, Avastin, pembrolizumab. It is best to read this information with our general information about the type of cancer you have.. Interferon is a type of immunotherapy drug called an immune system modulator. It is used to treat hepatitis B and C infections. Hypersensitivity to human interferon alpha proteins, mouse IgG, egg proteins, or neomycin. … Stay away from people with infections, colds, or flu. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Call your doctor or get medical You could have more side effects. You must check Long-term outcome of interferon-alpha-induced thyroid autoimmunity and prognostic influence of thyroid autoantibody pattern at the end of treatment. Flu-like signs. taken, how much, and when it happened. Closely read the part in this leaflet which lists when to call your doctor. Pegylated interferon alfa-2b, sold under the brand name PegIntron among others, is a medication used to treat hepatitis C and melanoma. If you have any questions about interferon alfa-2a, please talk Keep all drugs in a safe place. If your symptoms or health problems do not get better or if they become worse, call your doctor. Move the site where you give the shot with each shot. Alpha interferons may cause mental health problems or make them worse. Check with your pharmacist. Cavalheiro et al. This drug is approved around the world for the treatment of chronic hepatitis C, chronic hepatitis B, hairy cell leukemia, Behçet's disease, chronic myelogenous leukemia, multiple myeloma, follicular lymphoma, carcinoid tumor, mastocytosis and malignant melanoma. Avoid driving and doing other tasks or actions that call for you to be alert until you see how interferon alfa-2a affects you. There may be drug take-back programs in your area. Tell your doctor if you have ever had a low white blood cell count. autoimmune diseases worse. This medicine is screened, tested, and Interferon beta is a Type I interferon. If you think there has been an overdose, call your poison control center or get medical care right away. the last dose. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Do not give into skin that is irritated, bruised, red, infected, or scarred. Patients should be monitored closely with periodic clinical and laboratory evaluations. Tell your doctor about the allergy and Interferon alpha-2 is one of at least 23 different known variants of interferon alpha. Interferon alfa is well absorbed following IM or subcutaneous injection; the apparent fraction of the dose absorbed after IM or subcutaneous injection exceeds 80%. This medication is used to treat various cancers (e.g., leukemia, melanoma, AIDS-related Kaposi's sarcoma). In one of the initial studies, all 19 patients receiving intracystic interferon-alpha showed reduction in tumor size with a mean initial volume 33.50 cm 3 and mean final tumor volume of 3.10 cm 3. Throw syringe away after use. Interferon alfa-2b is a prescription medication used to treat chronic hepatitis B, chronic hepatitis C, certain type of genital warts, hairy cell leukemia, malignant melanoma, AIDS-related Kaposi's sarcoma, and follicular lymphoma.. Interferon alfa-2b belongs to a group of drugs called interferons. Interferon alfa-2a acts similarly to native interferon alpha. [Article in Japanese] Author J Imanishi 1 Affiliation 1 Dept. If you are allergic to interferon alfa-2a; any part of interferon alfa-2a; or any other drugs, foods, or substances. imiquimod topical, Aldara, interferon alfa-2b, Veregen, Condylox, Zyclara. Signs of liver problems like dark urine, feeling tired, not hungry. You may have more chance of getting an infection. Interferon alfa-2b is an antiviral or antineoplastic drug. If you have any questions about interferon alfa-n3, please talk Interferon beta used alone and in combination with ribavirin in patients with SARS and MERS has failed to show a significant positive effect on clinical outcomes. Talk with the doctor. Tell your doctor if you are pregnant or plan on getting pregnant. while you are pregnant. If you think there has been an overdose, call your poison control center or get medical care right away. Three forms of interferon— alpha (α), beta (β), and gamma (γ)—have been recognized. Last updated on Aug 8, 2020. BMJ Case Rep 2017; 2017. 4 Interferon alfa-2b, 5 recombinant 6 For Injection 7 8 WARNING 9 Alpha interferons, including INTRON® A, cause or aggravate fatal or life-threatening 10 neuropsychiatric, autoimmune, ischemic, and infectious disorders. If you have any of these health problems: Kidney disease or. In some cases, health care professionals may use the trade names Intron® A, Roferon®-A or other names such as IFN-alpha and alpha interferon when referring to the generic drug name interferon alfa. Fatigue (8-96%) Fever (34-94%) Neutropenia (92%) Flu-like syndrome (79%) Myalgia (28-75%) Anorexia (1-69%) Leukopenia (68%) Nausea (17-66%) Transaminases increased (13-63%) Weakness (63%) Headache (21-62%) Chills (54%) Diarrhea (2-45%) Rigors (42%) Depression (up to 40% of pts), suicidal ideation/ attempts, suicide Alopecia (38%) Dyspnea (34%) Somnolence (33%) Vomiting (2-32%) Anemia (32%) Cough (31%) Pharyngitis (31%) Chest pain (28%) Xerostomia (28%) Rash (25%) Dizziness (24%) Taste al… Throw away needles in a needle/sharp disposal box. kidney cancer; melanoma; carcinoid tumours; some types of lymphoma and leukaemia. For hepatitis C it is typically used with ribavirin and cure rates are between 33 and 82%. Do not have any kind of Suicide or suicidal thoughts, thoughts of hurting others, These interferons have been classified into two types: type I includes the alpha and beta forms, and type II consists of the gamma form. How you have interferon alfa. If you are 65 or older, use interferon alfa-2a with care. increased thirst tiredness urinating more often than normal increased appetite weight loss your breath smells like fruit Interferon lambda currently has no FDA approved uses, but researchers use it in research models of autoimmune disease … Interferons are currently used clinically to treat viral infections such as hepatitis C, cancers including non-Hodgkin’s lymphoma, and autoimmune diseases such as multiple sclerosis. 4. For all patients taking interferon alfa-2a: This is not a list of all drugs or health problems that interact with interferon alfa-2a. advice about side effects. FDA Approved Indications Interferon Alpha Alpha 2b - Pegintron (7) 1. Call your doctor right away if you have signs of infection like fever, chills, or … Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. with your doctor, nurse, pharmacist, or other health care provider. Follicular Lymphoma 4. Interferon alfa-2a side effects (in more detail). When the box is full, follow all local rules for Do not reuse needles or other items. advice about side effects. Not able to sleep. Cautions. This article provides clinical practice guidelines to assist practitioners and patients in making decisions about the indications and benefits of treatment with interferon for chronic viral hepatitis. Read all information given to you. INTRON ® A (Interferon alfa-2b) for intramuscular, subcutaneous, intralesional, or intravenous Injection is a purified sterile recombinant interferon product.. Intron A recombinant for Injection has been classified as an alpha interferon and is a water-soluble protein with a molecular weight of 19,271 daltons produced by recombinant DNA techniques. DESCRIPTION. Clinical Data for SARS and MERS. There may be drug take-back programs in your area. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Alpha interferons may cause mental health problems or make them worse. You may report side effects to the FDA at 1-800-332-1088. The major subtypes identified are IFN-α1, IFN-α2, IFN-α8, IFN-α10, IFN-α14 and IFN-α21. Be careful and avoid injury. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Interferon alfa-2b is an antiviral or antineoplastic drug. Do not flush down a toilet or pour down a drain unless you are told to do so. Throw away unused or expired drugs. Check your blood sugar as you have been told by your doctor. Interferon-alpha (or interferon-alfa) Interferon-beta; Interferon-gamma; Cells that have been infected with viruses or other germs give off interferon-alpha and interferon-beta as … [Interferon-alpha, beta, gamma] Gan To Kagaku Ryoho. If you are also taking other drugs, talk with your doctor about the Tell your doctor if you are pregnant or plan on getting pregnant. This may lead to a higher chance of getting an infection. This medicine may cause eye problems that may lead to loss of eyesight or blindness. Tell your doctor if you are breast-feeding. This includes your doctors, nurses, pharmacists, and dentists. Follow all instructions closely. Flu-like signs. Hypersensitivity to human interferon alpha proteins, mouse IgG, egg proteins, or neomycin. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten their anti-viral defenses. Interferon gamma enhances oxidative metabolism due to nitric oxide (NO) or NADPH oxidase products (e.g., superoxide, hydrogen peroxide, and hypohalous acid). Check with your PRODUCT INFORMATION INTRON A Interferon alfa-2b, For Injection A, cause or aggravate fatal or life-threatening neuropsychiatric, autoimmune, ischemic, and infectious disorders. Interferon alpha is currently recommended as an option for first-line therapy for individuals with essential thrombocythaemia or polycythaemia vera in whom cytoreduction is indicated. Do not flush down a toilet or pour down a drain unless you are told to do so. Tell all of your health care providers that you take interferon alfa-2a. That … This medicine does not stop the spread of diseases like HIV or hepatitis that are passed through blood or having sex. Interferon alfa-n3 side effects (in more detail). taken, how much, and when it happened. https://www.webmd.com/drugs/2/drug-76111/ribavirin-interferon-alfa-2b/details Tell your doctor if you have or have ever had eye You must check Induction of early regression of life-threatening corticosteroid resistant haemangiomata of infancy. Do not share your drugs with others and do not take anyone else's drugs. Keep all drugs out of the reach of children and pets. However, many people have no side effects or only have minor side effects. Relapse of drug addiction has also happened. It is given as a shot into the fatty part of the skin. Signs of low calcium levels like muscle cramps or spasms. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of Interferon alpha is currently recommended as an option for first-line therapy for individuals with essential thrombocythaemia or polycythaemia vera in whom cytoreduction is indicated. Talk with a doctor or pharmacist if you have any questions. This medicine is colorless to a faint yellow. Interferon alfa-2b treatment is to be restarted at 50% of the previous dose. Interferon alfa has shown some antitumour effect in certain lymphomas and solid tumours. Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor. Immune interferon (IFN-gamma; MIM 147570) is produced by mitogen- or antigen-stimulated T lymphocytes. Ask your doctor or pharmacist if you Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. Alpha interferons, including interferon alfa-2b, cause or aggravate fatal or life-threatening neuropsychiatric, autoimmune, ischemic, and infectious disorders. Interferons are a group of signaling proteins made and released by host cells in response to the presence of several viruses. any drug without checking with your doctor. Talk to your doctor about the risks of using this medication for your condition. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Interferon-alpha has been used as both systemic and intracavitary therapy for primary craniopharyngiomas. diabetes. Available for Android and iOS devices. Throw away unused or expired drugs. It is a recombinant form of the protein Interferon alpha-2 that was originally sequenced and produced recombinantly in E. coli in the laboratory of Charles Weissmann at the University of Zurich, in 1980. You will need to talk about any risks to your baby. Information about drug Interferon Alpha-2B includes cost of the drug and the type of drug - tablet, capsule, syrup, cream, gel, ointment, liquid or injection. Relapse of drug addiction has also happened. This medicine may be used with other drugs to treat your health condition. Description of Clinical Studies For melanoma it is used in addition to surgery. Suicide or suicidal thoughts, thoughts of hurting others, depression, forceful actions, hallucinations, and other mood or behavior problems have happened during treatment and within 6 months after the last dose. Wash hands often. Subcutaneous dosage. 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